英語論文/Original Research

2025
Aihara R, Takahashi M, Morino K, Matsubara K, Kunimura K, Nishikimi A, Izumi Y, Bamba T, Fukui Y, Uruno T.
Phospholipase D1 is a critical mediator of neutrophil extracellular trap formation and venous thrombosis.
Front Immunol. 16: 1666184.

Morino K, Akiyoshi S, Matsubara K, Sugiura Y, Izumi Y, Yotsumoto S, Yamamura K, Maeda R, Takahashi M, Nakata K, Bamba T, Nakahara T, Sakata D, Uruno T, Fukui Y, Kunimura K.
Sulfotransferase SULT2B1 contributes to the epithelial-immune microenvironment homeostasis in imiquimod-induced psoriatic dermatitis.
Front Immunol. 16: 1632426.

2023
Morino K, Kunimura K, Sugiura Y, Izumi Y, Matsubara K, Akiyoshi S, Maeda R, Hirotani K, Sakata D, Mizuno S, Takahashi S, Bamba T, Uruno T, Fukui Y.
Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury.
Front Immunol. 14: 1131146.

Kunimura K, Akiyoshi S, Uruno T, Matsubara K, Sakata D, Morino K, Hirotani K, Fukui Y.
DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.
J Allergy Clin Immunol. 151(6): 1585–1594.e9.

2022
Kunimura K, Yamamura K, Nakahara T, Kido-Nakahara M, Uruno T, Fukui Y.
Identification of a functional DOCK8 gene polymorphism associated with atopic dermatitis.
Allergy. 77(12): 3670–3672.

Tatsuguchi T*, Uruno T*#, Sugiura Y, Oisaki K, Takaya D, Sakata D, Izumi Y, Togo T, Hattori Y, Kunimura K, Sakurai T, Honma T, Bamba T, Nakamura M, Kanai M, Suematsu M, Fukui Y#.
Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity.
Biochem Biophys Res Commun. 609: 183–188.

Tatsuguchi T*, Uruno T*#, Sugiura Y, Sakata D, Izumi Y, Sakurai T, Hattori Y, Oki E, Kubota N, Nishimoto K, Oyama M, Kunimura K, Ohki T, Bamba T, Tahara H, Sakamoto M, Nakamura M, Suematsu M, Fukui Y#.
Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells.
Int Immunol. 34(5): 277–289.

2021
Matsubara K, Kunimura K, Yamane N, Aihara R, Sakurai T, Sakata D, Uruno T, Fukui Y.
DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells.
Biochem Biophys Res Commun. 559: 135–140.

Kamikaseda Y, Uruno T, Kunimura K, Harada A, Saiki K, Oisaki K, Sakata D, Nakahara T, Kido-Nakahara M, Kanai M, Nakamura S, Ohkawa Y, Furue M, Fukui Y.
Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.
J Allergy Clin Immunol. 148(2): 633–638.

Sakurai T, Kukimoto-Niino M, Kunimura K, Yamane N, Sakata D, Aihara R, Yasuda T, Yokoyama S, Shirouzu M, Fukui Y, Uruno T.
A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8.
Life Sci Alliance. 4(4): e202000873.

Aihara R, Kunimura K, Watanabe M, Uruno T, Yamane N, Sakurai T, Sakata D, Nishimura F, Fukui Y.
DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation.
Int Immunol. 33(3): 149–160.

2019

Kunimura K, Sakata D, Tun X, Uruno T, Ushijima M, Katakai T, Shiraishi A, Aihara R, Kamikaseda Y, Matsubara K, Kanegane H, Sawa S, Eberl G, Ohga S, Yoshikai Y, Fukui Y.

The S100A4 protein is essential for development of mature microfold cells in Peyer’s patches.

Cell Rep. 29: 2823–2834.

Sakata D, Uruno T, Matsubara K, Andoh T, Yamamura K, Magoshi Y, Kunimura K, Kamikaseda Y, Furue M, Fukui Y.
Selective role of neurokinin B in IL-31-induced itch response in mice.
J Allergy Clin Immunol. 144(4): 1130–1133.e8.

2018
Sakurai T*, Uruno T*, Sugiura Y, Tatsuguchi T, Yamamura K, Ushijima M, Hattori Y, Kukimoto-Niino M, Mishima-Tsumagari C, Watanabe M, Suematsu M, Fukui Y.
Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye.
Sci Signal. 11(541): eaao4874.

Ushijima M, Uruno T*, Nishikimi A, Sanematsu F, Kamikaseda Y, Kunimura K, Sakata D, Okada T, Fukui Y*.

The Rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production.

Front Immunol. 9: 243.

Tomino T, Tajiri H, Tatsuguchi T, Shirai T, Oisaki K, Matsunaga S, Sanematsu F, Sakata D, Yoshizumi T, Maehara Y, Kanai M, Côté JF, Fukui Y, Uruno T. 

DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation. 

Biochem Biophys Res Commun. 497: 298–304. 

2017

Tajiri H*, Uruno T*, Shirai T, Takaya D, Matsunaga S, Setoyama D, Watanabe M, Kukimoto-Niino M, Oisaki K, Ushijima M, Sanematsu F, Honma T, Terada T, Oki E, Shirasawa S, Maehara Y, Côté JF, Yokoyama S, Kanai M, Fukui Y.

Targeting Ras-driven cancer cell survival and invasion through selective inhibition of DOCK1.

Cell Rep. 19: 969–980.

Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.

Nat Commun. 8: 13946.

Shiraishi A, Uruno T, Sanematsu F, Ushijima M, Sakata D, Hara T, Fukui Y.

DOCK8 protein regulates macrophage migration through Cdc42 protein activation and LRAP35a protein interaction.

J Biol Chem. 292: 2191–2202.

Yanagihara T, Tomino T, Uruno T, Fukui Y.

Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes.

Biochem Biophys Res Commun. 489: 8–13. 

2015

Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Fukui Y.

Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.

Nat Commun. 6: 8820.

2014

Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Côté JF, Sumimoto H, Fukui Y. 

DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation. 

J Immunol. 193: 5660–5667. 

Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, Sanematsu F, Yamamura K, Terasawa M, Nishikimi A, Côté JF, Fukui Y. 

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation. 

J Exp Med. 211: 1407–1419. 

2012

Nishikimi A*, Uruno T*, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y.

Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.

Chem Biol. 19: 488–497.

Terasawa M*, Uruno T*, Mori S, Kukimoto-Niino M, Nishikimi A, Sanematsu F, Tanaka Y, Yokoyama S, Fukui Y.

Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.

PLoS One. 7: e46277.

Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S.

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.

Proc Natl Acad Sci U S A. 109: 3305–3310.

Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y.

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.

Blood. 119: 4451–4461.

2010

Gotoh K, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Maeda N, Ishikawa T, Hoshino K, Uruno T, Cao Q, Higashi S, Kawaguchi Y, Enjoji M, Takayanagi R, Kaisho T, Yoshikai Y, Fukui Y. 

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation. 

J Exp Med. 207: 721–730. 

Zwolak A*, Uruno T*, Piszczek G, Hammer JA 3rd, Tjandra N. 

Molecular basis for barbed end uncapping by CARMIL homology domain 3 of mouse CARMIL-1. 

J Biol Chem. 285: 29014–29026. 

2009

Remmert K, Uruno T, Hammer JA 3rd. 

Purification of capping protein using the capping protein binding site of CARMIL as an affinity matrix. 

Protein Expr Purif. 67: 113–119. 

2006

Uruno T, Remmert K, Hammer JA 3rd.

CARMIL is a potent capping protein antagonist: identification of a conserved CARMIL domain that inhibits the activity of capping protein and uncaps capped actin filaments.

J Biol Chem. 281: 10635–10650.

2004

Li Y, Uruno T, Haudenschild C, Dudek S, Garcia J, Zhan X.

Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell morphogenesis and migration.

Exp Cell Res. 298: 107–121.

2003

Uruno T, Zhang P, Liu J, Hao JJ, Zhan X. 

Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization. 

Biochem J. 371: 485–493. 

Uruno T, Liu J, Li Y, Smith N, Zhan X. 

Sequential interaction of Arp2/3 complex with N-WASP and cortactin during branched actin filament network formation. 

J Biol Chem. 278: 26086–26093. 

2002

Di Ciano C, Nie Z, Szaszi K, Lewis A, Uruno T, Zhan X, Rotstein OD, Mak A, Kapus A. 

Osmotic stress-induced remodeling of the cortical cytoskeleton. 

Am J Physiol Cell Physiol. 283: C850–C865. 

2001

Uruno T, Liu J, Zhang P, Fan YX, Egile C, Li R, Mueller SC, Zhan X.

Activation of Arp2/3 complex-mediated actin polymerization by cortactin.

Nat Cell Biol. 3: 259–266.

1999
Mizukoshi E, Suzuki M, Loupatov A, Uruno T, Hayashi H, Misono T, Kaul SC, Wadhwa R, Imamura T. 

Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin. 

Biochem J. 343: 461–466. 

Uruno T, Oki J, Ozawa K, Miyakawa K, Ueno H, Imamura T. 

Distinct regulation of myoblast differentiation by intracellular and extracellular fibroblast growth factor-1. 

Growth Factors. 17: 93–113. 

Miyakawa K, Ozawa K, Uruno T, Imamura T.
 The C-terminal region of fibroblast growth factor-1 is crucial for its biological activity and high-level protein expression in mammalian cells.
Growth Factors. 16: 191–200.

1996
Ozawa K, Uruno T, Miyakawa K, Seo M, Imamura T.
Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development.
Brain Res Mol Brain Res. 41: 279–288.

英文総説/Reviews

2020
Kunimura K, Uruno T, Fukui Y.
DOCK family proteins: key players in immune surveillance mechanisms.
Int Immunol. 32(1): 5–15.