英語論文/Original Research

2025
Aihara R, Takahashi M, Morino K, Matsubara K, Kunimura K, Nishikimi A, Izumi Y, Bamba T, Fukui Y, Uruno T.
Phospholipase D1 is a critical mediator of neutrophil extracellular trap formation and venous thrombosis.
Front Immunol. 16: 1666184.

Morino K, Akiyoshi S, Matsubara K, Sugiura Y, Izumi Y, Yotsumoto S, Yamamura K, Maeda R, Takahashi M, Nakata K, Bamba T, Nakahara T, Sakata D, Uruno T, Fukui Y, Kunimura K.
Sulfotransferase SULT2B1 contributes to the epithelial-immune microenvironment homeostasis in imiquimod-induced psoriatic dermatitis.
Front Immunol. 16: 1632426.

2023
Morino K, Kunimura K, Sugiura Y, Izumi Y, Matsubara K, Akiyoshi S, Maeda R, Hirotani K, Sakata D, Mizuno S, Takahashi S, Bamba T, Uruno T, Fukui Y.
Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury.
Front Immunol. 14: 1131146.

Kunimura K, Akiyoshi S, Uruno T, Matsubara K, Sakata D, Morino K, Hirotani K, Fukui Y.
DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.
J Allergy Clin Immunol. 151(6): 1585–1594.e9.

2022
Kunimura K, Yamamura K, Nakahara T, Kido-Nakahara M, Uruno T, Fukui Y.
Identification of a functional DOCK8 gene polymorphism associated with atopic dermatitis.
Allergy. 77(12): 3670–3672.

Tatsuguchi T, Uruno T, Sugiura Y, Oisaki K, Takaya D, Sakata D, Izumi Y, Togo T, Hattori Y, Kunimura K, Sakurai T, Honma T, Bamba T, Nakamura M, Kanai M, Suematsu M, Fukui Y.
Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity.
Biochem Biophys Res Commun. 609: 183–188.

Tatsuguchi T, Uruno T, Sugiura Y, Sakata D, Izumi Y, Sakurai T, Hattori Y, Oki E, Kubota N, Nishimoto K, Oyama M, Kunimura K, Ohki T, Bamba T, Tahara H, Sakamoto M, Nakamura M, Suematsu M, Fukui Y.
Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells.
Int Immunol. 34(5): 277–289.

2021
Matsubara K, Kunimura K, Yamane N, Aihara R, Sakurai T, Sakata D, Uruno T, Fukui Y.
DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells.
Biochem Biophys Res Commun. 559: 135–140.

Kamikaseda Y, Uruno T, Kunimura K, Harada A, Saiki K, Oisaki K, Sakata D, Nakahara T, Kido-Nakahara M, Kanai M, Nakamura S, Ohkawa Y, Furue M, Fukui Y.
Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.
J Allergy Clin Immunol. 148(2): 633–638.

Sakurai T, Kukimoto-Niino M, Kunimura K, Yamane N, Sakata D, Aihara R, Yasuda T, Yokoyama S, Shirouzu M, Fukui Y, Uruno T.
A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8.
Life Sci Alliance. 4(4): e202000873.

Aihara R, Kunimura K, Watanabe M, Uruno T, Yamane N, Sakurai T, Sakata D, Nishimura F, Fukui Y.
DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation.
Int Immunol. 33(3): 149–160.

更新中

2019
Sakata D, Uruno T, Matsubara K, Andoh T, Yamamura K, Magoshi Y, Kunimura K, Kamikaseda Y, Furue M, Fukui Y.
Selective role of neurokinin B in IL-31-induced itch response in mice.
J Allergy Clin Immunol. 144(4): 1130–1133.e8.

2018
Sakurai T, Uruno T, Sugiura Y, Tatsuguchi T, Yamamura K, Ushijima M, Hattori Y, Kukimoto-Niino M, Mishima-Tsumagari C, Watanabe M, Suematsu M, Fukui Y.
Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye.
Sci Signal. 11(541): eaao4874.

Ushijima M, Uruno T, Nishikimi A, Sanematsu F, Kamikaseda Y, Kunimura K, Sakata D, Okada T, Fukui Y.

The Rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production.

Front Immunol. 9: 243.

2017

Tajiri H, Uruno T, Shirai T, Takaya D, Matsunaga S, Setoyama D, Watanabe M, Kukimoto-Niino M, Oisaki K, Ushijima M, Sanematsu F, Honma T, Terada T, Oki E, Shirasawa S, Maehara Y, Côté JF, Yokoyama S, Kanai M, Fukui Y.

Targeting Ras-driven cancer cell survival and invasion through selective inhibition of DOCK1.

Cell Rep. 19: 969–980.

Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y.

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.

Nat Commun. 8: 13946.

2012

Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y.

Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.

Chem Biol. 19: 488–497.

2006

Uruno T, Remmert K, Hammer JA 3rd.

CARMIL is a potent capping protein antagonist: identification of a conserved CARMIL domain that inhibits the activity of capping protein and uncaps capped actin filaments.

J Biol Chem. 281: 10635–10650.

2001

Uruno T, Liu J, Zhang P, Fan YX, Egile C, Li R, Mueller SC, Zhan X.

Activation of Arp2/3 complex-mediated actin polymerization by cortactin.

Nat Cell Biol. 3: 259–266.

1999
Uruno T, Oki J, Ozawa K, Miyakawa K, Ueno H, Imamura T.
Distinct regulation of myoblast differentiation by intracellular and extracellular fibroblast growth factor-1.
Growth Factors. 17: 93–113.

1999
Uruno T, Oki J, Ozawa K, Miyakawa K, Ueno H, Imamura T.
Distinct regulation of myoblast differentiation by intracellular and extracellular fibroblast growth factor-1.
Growth Factors. 17: 93–113.

1999
Uruno T, Oki J, Ozawa K, Miyakawa K, Ueno H, Imamura T.
Distinct regulation of myoblast differentiation by intracellular and extracellular fibroblast growth factor-1.
Growth Factors. 17: 93–113.

1999
Miyakawa K, Ozawa K, Uruno T, Imamura T.
The C-terminal region of fibroblast growth factor-1 is crucial for its biological activity and high-level protein expression in mammalian cells.
Growth Factors. 16: 191–200.

1996
Ozawa K, Uruno T, Miyakawa K, Seo M, Imamura T.
Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development.
Brain Res Mol Brain Res. 41: 279–288.

英文総説/Reviews

2020
Kunimura K, Uruno T, Fukui Y.
DOCK family proteins: key players in immune surveillance mechanisms.
Int Immunol. 32(1): 5–15.